ExperimentSet4DNESW3L596Q
released
July 1st, 2019 at 2:42am
Source Publication
TSA-seq reveals a largely conserved genome organization relative to nuclear speckles with small position changes tightly correlated with gene expression changes.
Zhang L, Zhang Y, et al., Genome research 2020
TSA-seq Replicate Set with Biased Input Mapping
WARNING: One experiment in this set of replicates displays biased input mapping.
"Biased input" refers to input data sets that show unexpectedly large variations in read count over large chromosome domains that correlate with GC content as well as LAD/inter-LADs and early versus late DNA replication domains. They appear to be related to PCR bias during library construction. Input profiles typically are very similar from the same cell line between different experiments. TSA-Seq scores computed using input data from other experiments from the same cell line typically produce TSA-Seq scores significantly closer to TSA-Seq scores from replicate data sets which do not have biased input.
Experiment Set Properties
Set Type
Replicate
Organism
Sample Type
immortalized cells
Sample
Experiment Type(s)
Modification Type
None
Treatment Type
None
Assay Details
Target: SON protein