The 4D Nucleome Data Portal hosts data generated by the 4DN Network and other reference nucleomics data sets. The Portal is currently in pre-release as more data is being curated, and data processing and visualization tools are being incorporated. Click Browse to see currently available data.
The 4DN program aims to understand the principles underlying nuclear organization in space and time, the role nuclear organization plays in gene expression and cellular function, and how changes in nuclear organization affect normal development as well as various diseases. The program is developing novel tools to explore the dynamic nuclear architecture and its role in gene expression programs, models to examine the relationship between nuclear organization and function, and reference maps of nuclear architecture in a variety of cells and tissues as a community resource.
Part of the goals of 4DN involves generating reference data sets for selected cell types to study how different experiment types complement each other in our understanding of nucleome dynamics. Today, 4DN released reference Repli-seq data for the selected Tiered cell lines.
The first 4DN Funded Hi-C experiments have been released to public on the portal.
Ontology Terms from OBI, Uberon, and EFO are now represented on our database. Ontology terms can be internally used to describe cell lines and tissues. We will implement ontology utilization for other appropriate fields in the coming months.
The 4DN Data Portal is open for beta-testers for data submission for Hi-C and related experiments.