OntologyTerm motor neuron disease

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   May 11th, 2017 at 3:51pm

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definition 
A disease involving the motor neuron. -- Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089) (EFO)
namespace 
http://www.ebi.ac.uk/efo
parents 
  1. no view permissions
  2. neuromuscular disease
  3. neurodegenerative disease
preferred_name 
motor neuron disease
references 
  1. None
source_ontologies 
  1. Experimental Factor Ontology
synonyms 
  1. MOTOR NEURON DIS UPPER
  2. Anterior Horn Cell Disease
  3. motor neuron disease or disorder
  4. Lateral Scleroses
  5. Lateral Sclerosis
  6. MOTOR NEURON DIS
  7. MOTOR NEURON DIS LOWER
  8. SECOND MOTOR NEURON DIS
  9. Neuron Disease, Motor
  10. Scleroses, Lateral
  11. Motor Neuron Disease, Lower
  12. Lower Motor Neuron Disease
  13. Secondary Motor Neuron Disease
  14. MOTOR NEURON DIS FAMILIAL
  15. Motor Neuron Disease, Upper
  16. UPPER MOTOR NEURON DIS
  17. Motor Neuron Disease, Secondary
  18. Sclerosis, Lateral
  19. Upper Motor Neuron Disease
  20. Motor Neuron Disease, Familial
  21. ANTERIOR HORN CELL DIS
  22. Neuron Diseases, Motor
  23. Scleroses, Primary Lateral
  24. Motor System Diseases
  25. MOTOR NEURON DIS SECOND
  26. Motor Neuron Diseases
  27. motor neuron disease
  28. MOTOR SYSTEM DIS
  29. disease of motor neuron
  30. Motor System Disease
  31. disorder of motor neuron
  32. FAMILIAL MOTOR NEURON DIS
  33. LOWER MOTOR NEURON DIS
  34. anterior horn cell disease
  35. disease or disorder of motor neuron
  36. Familial Motor Neuron Disease
term_id 
EFO:0003782
term_name 
motor neuron disease
term_url 
http://www.ebi.ac.uk/efo/EFO_0003782