File4DNFIXWDLHDL
released
February 24th, 2019 at 7:57pm
WARNING: Biased Input Mapping
WARNING: This file was generated from a replicate experiment whose input reads displayed a mapping bias.
"Biased input" refers to input data sets that show unexpectedly large variations in read count over large chromosome domains that correlate with GC content as well as LAD/inter-LADs and early versus late DNA replication domains. They appear to be related to PCR bias during library construction. Input profiles typically are very similar from the same cell line between different experiments. TSA-Seq scores computed using input data from other experiments from the same cell line typically produce TSA-Seq scores significantly closer to TSA-Seq scores from replicate data sets which do not have biased input.
Note(s)
This file contains processed results performed outside of the 4DN-DCIC standardized pipelines. The file and the information about its provenance, i.e. which files were used as input to generate this output was provided by or done in collaboration with the lab that did the experiments to generate the raw data. For more information about the specific analysis performed, please contact the submitting lab or refer to the relevant publication if available.