Imaging a blank (no CTCF binding sites) 7.5kb insert as a control to confirm that the chromatin structural changes are not a result of the insert itself, but caused by the CTCF binding sites and flanking regions themselves.
CTCF mediates dosage- and sequence-context-dependent transcriptional insulation by forming local chromatin domains.
Huang H, Zhu Q, et al., Nature genetics 2021
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