{"ID": "PMID:32209126", "lab": {"display_title": "David Gilbert, SDBRI", "status": "current", "uuid": "6423b207-8176-4f06-a127-951b98d6a53a", "title": "David Gilbert, SDBRI", "@type": ["Lab", "Item"], "@id": "/labs/david-gilbert-lab/", "correspondence": [{"contact_email": "Z2lsYmVydEBzZGJyaS5vcmc=", "@id": "/users/1dbb8e49-38e4-4154-a97c-af8176a58c44/", "display_title": "David Gilbert"}], "pi": {"error": "no view permissions"}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin", "role.lab_submitter", "submits_for.6423b207-8176-4f06-a127-951b98d6a53a"]}}, "url": "https://www.ncbi.nlm.nih.gov/pubmed/32209126", "award": {"uuid": "91b694c3-f4d7-4ddd-8278-16f94e15c1c5", "project": "4DN", "@type": ["Award", "Item"], "display_title": "COMBINED CYTOLOGICAL, GENOMIC, AND FUNCTIONAL MAPPING OF NUCLEAR GENOME ORGANIZATION", "status": "current", "name": "1U54DK107965-01", "@id": "/awards/1U54DK107965-01/", "description": "NOFIC: Decades of microscopy have revealed that the nucleus is not a homogeneous organelle, but rather consists of distinct compartments such as nucleoli, nuclear speckles, the nuclear lamina, among other structures. Increasing evidence indicates that specific genomic regions each associate with these compartments. This genome compartmentalization has been linked to various functions, but these links are still poorly understood. Interestingly, Lamina Associated Domains (LADs) share specific heterochromatin marks, defining chromatin domains with distinct genetic and epigenetic properties. Genomic regions associating with other nuclear compartments may similarly define distinct classes of chromatin domains. One major bottleneck towards a deeper understanding of nuclear organization has been the inability to convert microscopy views of nuclear compartments into genome-wide maps that show which loci are associated with which compartment, and how the chromosomal fiber traverses between compartments. In addition, there is an urgent need for more efficient methods to dissect the mechanisms by which large genomic regions are targeted to specific nuclear compartments. Finally, there is an urgent need for high-throughput approaches that query the functional relevance of genome compartmentalization. For this Center grant, we propose to meet these needs through the following Aims: 1. Develop a strategy that connects microscopy views to genome-wide maps that, together with modeling, reveal the localization and dynamics of genomic regions relative to all major nuclear compartments. 2. Develop methods for efficient manipulation of the genome in order to elucidate mechanisms that target loci to specific compartments. 3. Develop methods to measure, model, and validate the functional relevance of nuclear compartments. The combined results of these approaches will reveal causal relationships now hidden among entangled genomic, epigenetic, and nuclear organization features. Deliverables of this proposal include a wide range of structural and functional maps of nuclear organization, reagents for visualizing endogenous chromosome loci, a powerful pipeline for synthesis of ~100kb DNA fragments, and cell lines facilitating repeated, high-fidelity insertio of these large fragments back into selected sites in the genome. These resources will provide a powerful complement to other 4D Nucleome Consortium efforts. A key strength of this Center proposal is the experience and complementary research capabilities of its five Investigators. Together they will pool their expertise for a concerted investigation into the biological functions of nuclear compartmentalization.", "center_title": "NOFIC - Belmont", "pi": {"error": "no view permissions"}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "title": "High-resolution Repli-Seq defines the temporal choreography of initiation, elongation and termination of replication in mammalian cells.", "status": "current", "aliases": ["4dn-dcic-lab:zhao_etal_hires_repli_2020_PMID_32209126"], "authors": ["Zhao PA", "Sasaki T", "Gilbert DM"], "journal": "Genome biology", "abstract": "BACKGROUND: DNA replication in mammalian cells occurs in a defined temporal order during S phase, known as the replication timing (RT) programme. Replication timing is developmentally regulated and correlated with chromatin conformation and local transcriptional potential. Here, we present RT profiles of unprecedented temporal resolution in two human embryonic stem cell lines, human colon carcinoma line HCT116, and mouse embryonic stem cells and their neural progenitor derivatives. RESULTS: Fine temporal windows revealed a remarkable degree of cell-to-cell conservation in RT, particularly at the very beginning and ends of S phase, and identified 5 temporal patterns of replication in all cell types, consistent with varying degrees of initiation efficiency. Zones of replication initiation (IZs) were detected throughout S phase and interacted in 3D space preferentially with other IZs of similar firing time. Temporal transition regions were resolved into segments of uni-directional replication punctuated at specific sites by small, inefficient IZs. Sites of convergent replication were divided into sites of termination or large constant timing regions consisting of many synchronous IZs in tandem. Developmental transitions in RT occured mainly by activating or inactivating individual IZs or occasionally by altering IZ firing time, demonstrating that IZs, rather than individual origins, are the units of developmental regulation. Finally, haplotype phasing revealed numerous regions of allele-specific and allele-independent asynchronous  replication. Allele-independent asynchronous replication was correlated with the  presence of previously mapped common fragile sites. CONCLUSIONS: Altogether, these data provide a detailed temporal choreography of DNA replication in mammalian cells.", "date_created": "2021-08-25T16:36:26.682896+00:00", "published_by": "4DN", "submitted_by": {"error": "no view permissions"}, "last_modified": {"modified_by": {"error": "no view permissions"}, "date_modified": "2021-08-25T17:00:03.070214+00:00"}, "date_published": "2020-03-24", "public_release": "2021-08-25", "schema_version": "2", "project_release": "2021-08-25", "exp_sets_prod_in_pub": [{"accession": "4DNES2W2DXM6", "status": "released", "@id": "/experiment-set-replicates/4DNES2W2DXM6/", "uuid": "6f78cd0b-a8e3-406a-b157-bf1c02eec426", "@type": ["ExperimentSetReplicate", "ExperimentSet", "Item"], "display_title": "4DNES2W2DXM6", "experimentset_type": "replicate", "experiments_in_set": [{"@id": "/experiments-repliseq/4DNEXDRZLEQV/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "2a241f5c-f2f2-44ce-a0dd-264e38be62f0", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) G1-phase G1 - 4DNEXDRZLEQV", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEX6Q73J7B/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "1a176105-b489-494f-a044-668f13fb24f8", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) G1-phase G1 - 4DNEX6Q73J7B", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}], "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"accession": "4DNES8GLHOD6", "status": "released", "@id": "/experiment-set-replicates/4DNES8GLHOD6/", "uuid": "9a2f3cd8-441d-420a-8d75-d8eb62183651", "@type": ["ExperimentSetReplicate", "ExperimentSet", "Item"], "display_title": "4DNES8GLHOD6", "experimentset_type": "replicate", "experiments_in_set": [{"@id": "/experiments-repliseq/4DNEXL6WTINA/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "a408f136-aac7-4be7-a332-a2e2032bc25f", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P2 - 4DNEXL6WTINA", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEXSK4XA98/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "a98aeeda-b640-4768-8878-8a17b9965024", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P2 - 4DNEXSK4XA98", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}], "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"accession": "4DNESWWMQ1IC", "status": "released", "@id": "/experiment-set-replicates/4DNESWWMQ1IC/", "uuid": "c64c1a71-e9e6-4842-bf69-01dd404e24d4", "@type": ["ExperimentSetReplicate", "ExperimentSet", "Item"], "display_title": "4DNESWWMQ1IC", "experimentset_type": "replicate", "experiments_in_set": [{"@id": "/experiments-repliseq/4DNEXKCP8338/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "f43e24e1-da36-4ac9-a42f-5f9abebec876", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P3 - 4DNEXKCP8338", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEXZH8PQ2D/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "78141041-97c6-4a8c-8d88-1545090b283e", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P3 - 4DNEXZH8PQ2D", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}], "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"accession": "4DNES2LV4C4Q", "status": "released", "@id": "/experiment-set-replicates/4DNES2LV4C4Q/", "uuid": "fbc776d3-c6f0-46bd-ba91-e61f16622057", "@type": ["ExperimentSetReplicate", "ExperimentSet", "Item"], "display_title": "4DNES2LV4C4Q", "experimentset_type": "replicate", "experiments_in_set": [{"@id": "/experiments-repliseq/4DNEX5M9XSGK/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "92304a00-94c9-494d-b80d-90c10fbc4745", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P4 - 4DNEX5M9XSGK", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEX7KPBKXE/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "de1d01c6-2397-4935-936b-71917ca4649b", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P4 - 4DNEX7KPBKXE", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}], "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"accession": "4DNES2RXY8IB", "status": "released", "@id": "/experiment-set-replicates/4DNES2RXY8IB/", "uuid": "0ea5e15d-bb12-47eb-be4b-ff09ea6ae356", "@type": ["ExperimentSetReplicate", "ExperimentSet", "Item"], "display_title": "4DNES2RXY8IB", "experimentset_type": "replicate", "experiments_in_set": [{"@id": "/experiments-repliseq/4DNEXEQB7RNA/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "b60b21f4-7613-4a40-9ad1-e776ca660da0", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P5 - 4DNEXEQB7RNA", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEXXYBNRD1/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "43d1e344-457b-4d3c-95d5-e527651fc6ea", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P5 - 4DNEXXYBNRD1", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}], "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"accession": "4DNESVX7IH76", "status": "released", "@id": "/experiment-set-replicates/4DNESVX7IH76/", "uuid": "c1702124-eef1-4b38-8529-2a9298981fa3", "@type": ["ExperimentSetReplicate", "ExperimentSet", "Item"], "display_title": "4DNESVX7IH76", "experimentset_type": "replicate", "experiments_in_set": [{"@id": "/experiments-repliseq/4DNEXQ4EXW3K/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "f533fadd-1645-4440-8349-61e83c4e684a", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P6 - 4DNEXQ4EXW3K", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEXJ9B1OWZ/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "40fb1b98-9a14-41e4-bca8-9e3d1321b28f", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P6 - 4DNEXJ9B1OWZ", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}], "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"accession": "4DNESLOM1MB7", "status": "released", "@id": "/experiment-set-replicates/4DNESLOM1MB7/", "uuid": "3b0a2055-7699-437e-ba40-85a29873d36b", "@type": ["ExperimentSetReplicate", "ExperimentSet", "Item"], "display_title": "4DNESLOM1MB7", "experimentset_type": "replicate", "experiments_in_set": [{"@id": "/experiments-repliseq/4DNEXS77PTUK/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "d47f0738-e001-493e-b378-4d2ed1d33a4c", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P7 - 4DNEXS77PTUK", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEX3WC3JH3/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "d7ff3019-0f39-4505-be46-d2cfcd527dd4", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P7 - 4DNEX3WC3JH3", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}], "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"accession": "4DNESR9FVS6K", "status": "released", "@id": "/experiment-set-replicates/4DNESR9FVS6K/", "uuid": "84b8bd48-5139-4790-aac0-4654c5d26000", "@type": ["ExperimentSetReplicate", "ExperimentSet", "Item"], "display_title": "4DNESR9FVS6K", "experimentset_type": "replicate", "experiments_in_set": [{"@id": "/experiments-repliseq/4DNEX8K5TT7Y/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "252d7343-7760-40f3-a0eb-52d01ba66b4f", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P8 - 4DNEX8K5TT7Y", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEXDNSSMPJ/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "abfd642a-f6af-46c2-99a7-269ff37cde1a", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P8 - 4DNEXDNSSMPJ", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}], "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"accession": "4DNESFMEOEHW", "status": "released", "@id": "/experiment-set-replicates/4DNESFMEOEHW/", "uuid": "31689d6c-9bf0-499f-8e23-270828bb7580", "@type": ["ExperimentSetReplicate", "ExperimentSet", "Item"], "display_title": "4DNESFMEOEHW", "experimentset_type": "replicate", "experiments_in_set": [{"@id": "/experiments-repliseq/4DNEXTM3PBS3/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "15862f9f-7328-4bbe-a726-fb0710e4adf8", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P9 - 4DNEXTM3PBS3", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEX7T7A9QP/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "1fc7e9f9-b6db-4985-b658-d0edca6e3106", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P9 - 4DNEX7T7A9QP", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}], "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"accession": "4DNESBZIJJ1E", "status": "released", "@id": "/experiment-set-replicates/4DNESBZIJJ1E/", "uuid": "bec367bd-52c2-4dbf-9583-7e5fc30d5e9d", "@type": ["ExperimentSetReplicate", "ExperimentSet", "Item"], "display_title": "4DNESBZIJJ1E", "experimentset_type": "replicate", "experiments_in_set": [{"@id": "/experiments-repliseq/4DNEXDWEK1ME/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "40f340df-7f5e-4984-84f7-90e819769007", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P10 - 4DNEXDWEK1ME", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEX8GYBZDB/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "0743117d-d3ee-41fb-9d44-bd1e41ba0a1c", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P10 - 4DNEX8GYBZDB", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}], "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"accession": "4DNESDZOL2VU", "status": "released", "@id": "/experiment-set-replicates/4DNESDZOL2VU/", "uuid": "1f0a4bd4-d3ee-49fa-9432-7967e6102485", "@type": ["ExperimentSetReplicate", "ExperimentSet", "Item"], "display_title": "4DNESDZOL2VU", "experimentset_type": "replicate", "experiments_in_set": [{"@id": "/experiments-repliseq/4DNEXZPBA82F/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "fcf143b6-740c-440d-8abf-7aaa47519017", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P11 - 4DNEXZPBA82F", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEXEYRHQ6L/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "970bcb35-6e9d-4f95-bc0b-97833429fcca", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P11 - 4DNEXEYRHQ6L", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}], "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"accession": "4DNESJJKOIH4", "status": "released", "@id": "/experiment-set-replicates/4DNESJJKOIH4/", "uuid": "6922e877-0e0d-4eca-9814-8f6d927b2ab1", "@type": ["ExperimentSetReplicate", "ExperimentSet", "Item"], "display_title": "4DNESJJKOIH4", "experimentset_type": "replicate", "experiments_in_set": [{"@id": "/experiments-repliseq/4DNEX1BWBWFA/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "b2c67621-de42-4301-bf47-386f5d79f326", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P12 - 4DNEX1BWBWFA", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEXJ185GTQ/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "dbd144b9-ee0f-4cc9-8368-a121af0bbfce", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P12 - 4DNEXJ185GTQ", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}], "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"accession": "4DNES4I9OXS7", "status": "released", "@id": "/experiment-set-replicates/4DNES4I9OXS7/", "uuid": "d231d0ee-aa49-458b-85f0-a6432bacb446", "@type": ["ExperimentSetReplicate", "ExperimentSet", "Item"], "display_title": "4DNES4I9OXS7", "experimentset_type": "replicate", "experiments_in_set": [{"@id": "/experiments-repliseq/4DNEXLVWLA33/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "d2e31e8d-29c8-4bc7-8c76-7a7009e76e76", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P13 - 4DNEXLVWLA33", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEX5DWF6FC/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "2438645a-5c4f-43ce-9b11-8937b9afa97b", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P13 - 4DNEX5DWF6FC", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}], "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"accession": "4DNES6G2SSN2", "status": "released", "@id": "/experiment-set-replicates/4DNES6G2SSN2/", "uuid": "e9eeeb56-28d8-41b8-b245-cb22f727b6d1", "@type": ["ExperimentSetReplicate", "ExperimentSet", "Item"], "display_title": "4DNES6G2SSN2", "experimentset_type": "replicate", "experiments_in_set": [{"@id": "/experiments-repliseq/4DNEXXIXTTXI/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "a92f050e-5b6c-4e7f-bb6b-693b951a0bcc", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P14 - 4DNEXXIXTTXI", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEXFRYPDNV/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "4e365c80-db36-4279-8c31-ec088ebdafa2", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P14 - 4DNEXFRYPDNV", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}], "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"accession": "4DNESGY7RRTV", "status": "released", "@id": "/experiment-set-replicates/4DNESGY7RRTV/", "uuid": "496fad43-b143-47fc-a04b-0e2b56bea449", "@type": ["ExperimentSetReplicate", "ExperimentSet", "Item"], "display_title": "4DNESGY7RRTV", "experimentset_type": "replicate", "experiments_in_set": [{"@id": "/experiments-repliseq/4DNEXCTB91SG/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "a06f8505-a520-4bfe-bac8-72c9d786b47f", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P15 - 4DNEXCTB91SG", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEX65GM2L2/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "0f3f8eec-2cb9-4ba8-8dfd-16a9dfbaec71", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P15 - 4DNEX65GM2L2", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}], "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"accession": "4DNESYIVVMOC", "status": "released", "@id": "/experiment-set-replicates/4DNESYIVVMOC/", "uuid": "896b6371-e325-4411-99fd-0fd6ef3936f6", "@type": ["ExperimentSetReplicate", "ExperimentSet", "Item"], "display_title": "4DNESYIVVMOC", "experimentset_type": "replicate", "experiments_in_set": [{"@id": "/experiments-repliseq/4DNEXYX58PCM/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "a69af64f-6eff-4aee-848f-5e30a51fd533", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P16 - 4DNEXYX58PCM", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEX28OSAGW/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "9fa622cf-72c6-4725-8e54-f34bea6fe9d0", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P16 - 4DNEX28OSAGW", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}], "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"accession": "4DNESIK2HK47", "status": "released", "@id": "/experiment-set-replicates/4DNESIK2HK47/", "uuid": "1042e2ec-ccb6-465b-a34f-98fad82d533f", "@type": ["ExperimentSetReplicate", "ExperimentSet", "Item"], "display_title": "4DNESIK2HK47", "experimentset_type": "replicate", "experiments_in_set": [{"@id": "/experiments-repliseq/4DNEXKP295JF/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "6fbf5b5b-dedc-447d-b796-d6255a482f3f", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P17 - 4DNEXKP295JF", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEXO1I4HLD/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "d7b627ba-5fdb-44f3-983f-ccfd2afc963b", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P17 - 4DNEXO1I4HLD", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}], "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"accession": "4DNESXRBILXJ", "status": "released", "@id": "/experiment-sets/4DNESXRBILXJ/", "uuid": "2dc82177-cb40-4de6-b029-745d9ecd5a54", "@type": ["ExperimentSet", "Item"], "display_title": "4DNESXRBILXJ", "experimentset_type": "custom", "experiments_in_set": [{"@id": "/experiments-repliseq/4DNEXXYBNRD1/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "43d1e344-457b-4d3c-95d5-e527651fc6ea", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P5 - 4DNEXXYBNRD1", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEXZPBA82F/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "fcf143b6-740c-440d-8abf-7aaa47519017", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P11 - 4DNEXZPBA82F", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEXXIXTTXI/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "a92f050e-5b6c-4e7f-bb6b-693b951a0bcc", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P14 - 4DNEXXIXTTXI", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEXSK4XA98/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "a98aeeda-b640-4768-8878-8a17b9965024", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P2 - 4DNEXSK4XA98", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEX28OSAGW/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "9fa622cf-72c6-4725-8e54-f34bea6fe9d0", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P16 - 4DNEX28OSAGW", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEXKCP8338/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "f43e24e1-da36-4ac9-a42f-5f9abebec876", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P3 - 4DNEXKCP8338", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEX7T7A9QP/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "1fc7e9f9-b6db-4985-b658-d0edca6e3106", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P9 - 4DNEX7T7A9QP", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEXZH8PQ2D/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "78141041-97c6-4a8c-8d88-1545090b283e", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P3 - 4DNEXZH8PQ2D", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEXYX58PCM/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "a69af64f-6eff-4aee-848f-5e30a51fd533", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P16 - 4DNEXYX58PCM", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEXL6WTINA/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "a408f136-aac7-4be7-a332-a2e2032bc25f", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P2 - 4DNEXL6WTINA", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEX6Q73J7B/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "1a176105-b489-494f-a044-668f13fb24f8", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) G1-phase G1 - 4DNEX6Q73J7B", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEX7KPBKXE/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "de1d01c6-2397-4935-936b-71917ca4649b", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P4 - 4DNEX7KPBKXE", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEX1BWBWFA/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "b2c67621-de42-4301-bf47-386f5d79f326", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P12 - 4DNEX1BWBWFA", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEXDRZLEQV/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "2a241f5c-f2f2-44ce-a0dd-264e38be62f0", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) G1-phase G1 - 4DNEXDRZLEQV", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEXFRYPDNV/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "4e365c80-db36-4279-8c31-ec088ebdafa2", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P14 - 4DNEXFRYPDNV", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEXCTB91SG/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "a06f8505-a520-4bfe-bac8-72c9d786b47f", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P15 - 4DNEXCTB91SG", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEXJ9B1OWZ/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "40fb1b98-9a14-41e4-bca8-9e3d1321b28f", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P6 - 4DNEXJ9B1OWZ", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEX65GM2L2/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "0f3f8eec-2cb9-4ba8-8dfd-16a9dfbaec71", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P15 - 4DNEX65GM2L2", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEXTM3PBS3/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "15862f9f-7328-4bbe-a726-fb0710e4adf8", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P9 - 4DNEXTM3PBS3", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEXDWEK1ME/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "40f340df-7f5e-4984-84f7-90e819769007", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P10 - 4DNEXDWEK1ME", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEXS77PTUK/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "d47f0738-e001-493e-b378-4d2ed1d33a4c", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P7 - 4DNEXS77PTUK", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEX5DWF6FC/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "2438645a-5c4f-43ce-9b11-8937b9afa97b", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P13 - 4DNEX5DWF6FC", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEXJ185GTQ/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "dbd144b9-ee0f-4cc9-8368-a121af0bbfce", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P12 - 4DNEXJ185GTQ", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEX8K5TT7Y/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "252d7343-7760-40f3-a0eb-52d01ba66b4f", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P8 - 4DNEX8K5TT7Y", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEXKP295JF/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "6fbf5b5b-dedc-447d-b796-d6255a482f3f", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P17 - 4DNEXKP295JF", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEXEYRHQ6L/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "970bcb35-6e9d-4f95-bc0b-97833429fcca", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P11 - 4DNEXEYRHQ6L", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEX5M9XSGK/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "92304a00-94c9-494d-b80d-90c10fbc4745", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P4 - 4DNEX5M9XSGK", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEX8GYBZDB/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "0743117d-d3ee-41fb-9d44-bd1e41ba0a1c", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P10 - 4DNEX8GYBZDB", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEXDNSSMPJ/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "abfd642a-f6af-46c2-99a7-269ff37cde1a", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P8 - 4DNEXDNSSMPJ", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEX3WC3JH3/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "d7ff3019-0f39-4505-be46-d2cfcd527dd4", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P7 - 4DNEX3WC3JH3", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEXLVWLA33/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "d2e31e8d-29c8-4bc7-8c76-7a7009e76e76", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P13 - 4DNEXLVWLA33", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEXO1I4HLD/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "d7b627ba-5fdb-44f3-983f-ccfd2afc963b", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P17 - 4DNEXO1I4HLD", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEXQ4EXW3K/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "f533fadd-1645-4440-8349-61e83c4e684a", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P6 - 4DNEXQ4EXW3K", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"@id": "/experiments-repliseq/4DNEXEQB7RNA/", "@type": ["ExperimentRepliseq", "Experiment", "Item"], "uuid": "b60b21f4-7613-4a40-9ad1-e776ca660da0", "display_title": "Multi-stage Repli-seq on H1-hESC (Tier 1) S-phase P5 - 4DNEXEQB7RNA", "status": "released", "experiment_type": {"@id": "/experiment-types/multi-stage-repli-seq/", "display_title": "Multi-stage Repli-seq", "title": "Multi-stage Repli-seq", "@type": ["ExperimentType", "Item"], "status": "released", "uuid": "a81c2c5a-7bec-46cf-ba78-db93fde25ca8", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}], "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}], "@id": "/publications/7f3c096b-38fc-4fc1-abf8-679e8d90e9dd/", "@type": ["Publication", "Item"], "uuid": "7f3c096b-38fc-4fc1-abf8-679e8d90e9dd", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}, "display_title": "Zhao PA et al. (2020) PMID:32209126", "external_references": [], "short_attribution": "Zhao PA et al. (2020)", "number_of_experiment_sets": 18, "@context": "/terms/", "aggregated-items": {}, "validation-errors": []}