{"lab": {"uuid": "ce54a7f7-af8a-4505-8327-e430634f494b", "title": "Rafael Casellas, NIH", "@type": ["Lab", "Item"], "@id": "/labs/rafael-casellas-lab/", "correspondence": [{"contact_email": "Y2FzZWxsYXJAbWFpbC5uaWguZ292", "@id": "/users/68b09572-0c3e-48c7-90a9-7bad21d6bac1/", "display_title": "Rafael Casellas"}], "display_title": "Rafael Casellas, NIH", "status": "current", "pi": {"error": "no view permissions"}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin", "role.lab_submitter", "submits_for.ce54a7f7-af8a-4505-8327-e430634f494b"]}}, "tags": ["strandedness_verified"], "award": {"center_title": "External", "@id": "/awards/external-award/", "status": "current", "@type": ["Award", "Item"], "project": "External", "center": "External", "display_title": "EXTERNAL AWARD", "description": "Funding source is from outside 4DN.", "name": "external-award", "uuid": "12a92962-8265-4fc0-b2f8-cf14f05db58b", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "files": [{"file_type": "reads", "status": "released", "@id": "/files-fastq/4DNFIAQ3ZY3Z/", "accession": "4DNFIAQ3ZY3Z", "file_type_detailed": "reads (fastq)", "uuid": "9850e1ed-9c00-476a-828f-06387d4ca0f1", "upload_key": "9850e1ed-9c00-476a-828f-06387d4ca0f1/4DNFIAQ3ZY3Z.fastq.gz", "display_title": "4DNFIAQ3ZY3Z.fastq.gz", "file_classification": "raw file", "@type": ["FileFastq", "File", "Item"], "dbxrefs": ["SRA:SRR5470743"], "href": "/files-fastq/4DNFIAQ3ZY3Z/@@download/4DNFIAQ3ZY3Z.fastq.gz", "file_size": 1931620642, "quality_metric": {"url": "https://s3.amazonaws.com/elasticbeanstalk-fourfront-webprod-wfoutput/4DNFIAQ3ZY3Z/fastqc_report.html", "display_title": "QualityMetricFastqc from 2018-11-27", "Sequence length": "50", "Total Sequences": 35841752, "status": "released", "overall_quality_status": "PASS", "@id": "/quality-metrics-fastqc/1f006795-1e5c-4da9-b874-a94eafc404fa/", "@type": ["QualityMetricFastqc", "QualityMetric", "Item"], "uuid": "1f006795-1e5c-4da9-b874-a94eafc404fa", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}, "file_format": {"status": "released", "display_title": "fastq", "uuid": "c13d06cf-218e-4f61-aaf0-91f226248b2c", "@id": "/file-formats/fastq/", "file_format": "fastq", "@type": ["FileFormat", "Item"], "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "external_references": [{"ref": "SRA:SRR5470743", "uri": "https://www.ncbi.nlm.nih.gov/sra/?term=SRR5470743"}]}], "status": "released", "aliases": ["4dn-dcic-lab:GSM2587427"], "dbxrefs": ["GEO:GSM2587427"], "accession": "4DNEXDWSGYS9", "biosample": {"modifications_summary": "None", "status": "released", "uuid": "3d9e9e74-4194-4947-a085-d91db3fd3111", "treatments_summary": "None", "@id": "/biosamples/4DNBSMPEGHY3/", "biosample_type": "immortalized cells", "biosource_summary": "CH12", "@type": ["Biosample", "Item"], "accession": "4DNBSMPEGHY3", "display_title": "4DNBSMPEGHY3", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}, "biosource": [{"lab": {"@type": ["Lab", "Item"], "status": "current", "display_title": "4DN DCIC, HMS", "uuid": "828cd4fe-ebb0-4b36-a94a-d2e3a36cc989", "@id": "/labs/4dn-dcic-lab/", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin", "role.lab_submitter", "submits_for.828cd4fe-ebb0-4b36-a94a-d2e3a36cc989"]}}, "award": {"uuid": "b0b9c607-f8b4-4f02-93f4-9895b461334b", "@id": "/awards/1U01CA200059-01/", "status": "current", "@type": ["Award", "Item"], "display_title": "4D NUCLEOME NETWORK DATA COORDINATION AND INTEGRATION CENTER - PHASE I", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "status": "released", "tissue": {"@id": "/ontology-terms/CL:0000945/", "display_title": "B-lymphocyte", "slim_terms": [{"display_title": "cell", "@id": "/ontology-terms/CL:0000000/", "uuid": "45d2b02e-130b-40db-8bf2-2288c6c57dcf", "status": "released", "@type": ["OntologyTerm", "Item"], "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"display_title": "immune system", "@id": "/ontology-terms/UBERON:0002405/", "uuid": "111133bc-8535-4448-903e-854af460a233", "status": "released", "@type": ["OntologyTerm", "Item"], "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"display_title": "cell", "@id": "/ontology-terms/GO:0005623/", "uuid": "72e16a19-eef3-46ca-a1b8-20e646e69675", "status": "current", "@type": ["OntologyTerm", "Item"], "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}], "status": "released", "term_id": "CL:0000945", "@type": ["OntologyTerm", "Item"], "uuid": "0c98ef0b-9a03-43f3-b409-fb091e62e2f8", "preferred_name": "B-lymphocyte", "term_name": "lymphocyte of B lineage", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "aliases": ["4dn-dcic-lab:biosource-CH12"], "accession": "4DNSRPNYPN22", "cell_line": {"@id": "/ontology-terms/4DN:0000263/", "status": "released", "term_id": "4DN:0000263", "preferred_name": "CH12", "@type": ["OntologyTerm", "Item"], "term_name": "CH12", "uuid": "8647e451-5e4c-41d1-98b6-b3c57226fbb3", "slim_terms": [{"@type": ["OntologyTerm", "Item"], "uuid": "72e16a19-eef3-46ca-a1b8-20e646e69675", "display_title": "cell", "status": "current", "@id": "/ontology-terms/GO:0005623/", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}], "display_title": "CH12", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "individual": {"@type": ["IndividualMouse", "Individual", "Item"], "@id": "/individuals-mouse/4DNINGX2D3T7/", "display_title": "4DNINGX2D3T7", "uuid": "a247155e-e826-464e-ae9a-ac1f0017af64", "status": "released", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "description": "CH12 B lymphoma cell line", "date_created": "2018-11-27T16:42:12.307834+00:00", "submitted_by": {"error": "no view permissions"}, "last_modified": {"modified_by": {"error": "no view permissions"}, "date_modified": "2019-11-25T02:46:35.760932+00:00"}, "biosource_type": "immortalized cell line", "cell_line_tier": "Unclassified", "public_release": "2019-11-25", "schema_version": "2", "project_release": "2019-11-25", "@id": "/biosources/4DNSRPNYPN22/", "@type": ["Biosource", "Item"], "uuid": "5c4f486e-4f36-4d57-a38a-966e0ea29716", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}, "display_title": "CH12 - 4DNSRPNYPN22", "external_references": [], "biosource_name": "CH12", "biosource_category": ["Other"], "organism": {"uuid": "3413218c-3d86-498b-a0a2-9a406638e786", "name": "mouse", "display_title": "M. musculus", "@type": ["Organism", "Item"], "status": "released", "@id": "/organisms/10090/", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}}], "badges": [{"messages": ["Biosample missing Cell Culture Details"], "badge": {"badge_classification": "Warning", "display_title": "Biosample Metadata Incomplete", "uuid": "2b2cc7ff-b7a8-4138-9a6c-22884fc71690", "description": "Biosample is missing metadata information required as part of the standards implemented by the 4DN Samples working group.", "badge_icon": "/static/img/badges/biosample-icon.svg", "status": "released", "warning": "Biosample Metadata Incomplete", "@id": "/badges/biosample-metadata-incomplete/", "title": "Biosample Metadata Incomplete", "@type": ["Badge", "Item"], "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}}]}, "description": "mRNA-seq on CH12 Replicate:GSM2587427_ch12_wt_mRNA_rep2", "sop_mapping": {"has_sop": "No"}, "date_created": "2018-11-27T18:26:06.674867+00:00", "strandedness": "unstranded", "submitted_by": {"error": "no view permissions"}, "last_modified": {"modified_by": {"error": "no view permissions"}, "date_modified": "2019-12-03T20:08:21.526904+00:00"}, "public_release": "2019-12-03", "schema_version": "5", "experiment_type": {"experiment_category": "Sequencing", "display_title": "RNA-seq", "assay_subclass_short": "Transcription", "@id": "/experiment-types/rna-seq/", "status": "released", "uuid": "19f848e6-7c52-4b8b-8aa8-e82ea0a968ce", "title": "RNA-seq", "@type": ["ExperimentType", "Item"], "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "processed_files": [{"upload_key": "a2bec392-a9a6-4de0-b1f6-df4e635baf33/4DNFI5EPNX3A.bam", "href": "/files-processed/4DNFI5EPNX3A/@@download/4DNFI5EPNX3A.bam", "accession": "4DNFI5EPNX3A", "file_size": 3161364619, "@type": ["FileProcessed", "File", "Item"], "file_type_detailed": "read positions (bam)", "open_data_url": "https://4dn-open-data-public.s3.amazonaws.com/fourfront-webprod/wfoutput/a2bec392-a9a6-4de0-b1f6-df4e635baf33/4DNFI5EPNX3A.bam", "file_format": {"display_title": "bam", "@type": ["FileFormat", "Item"], "file_format": "bam", "@id": "/file-formats/bam/", "uuid": "d13d06cf-218e-4f61-aaf0-91f226248b3c", "status": "released", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "file_type": "read positions", "file_classification": "processed file", "status": "released", "display_title": "4DNFI5EPNX3A.bam", "@id": "/files-processed/4DNFI5EPNX3A/", "uuid": "a2bec392-a9a6-4de0-b1f6-df4e635baf33", "quality_metric": {"@id": "/quality-metrics-rnaseq/2fd75a58-80e5-4f71-adbe-30ac47378df5/", "status": "released", "overall_quality_status": "PASS", "@type": ["QualityMetricRnaseq", "QualityMetric", "Item"], "display_title": "QualityMetricRnaseq from 2019-11-28", "uuid": "2fd75a58-80e5-4f71-adbe-30ac47378df5", "quality_metric_summary": [{"title": "Total mapped reads (genome)", "value": "34596024", "numberType": "integer"}, {"title": "Total uniquely mapped reads (genome)", "value": "26341059", "numberType": "integer"}], "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "track_and_facet_info": {"experimental_lab": "Rafael Casellas, NIH", "experiment_type": "RNA-seq", "experiment_bucket": "processed file", "dataset": "RNA-seq on CH12", "condition": "WT", "replicate_info": "Biorep 2, Techrep 1", "biosource_name": "CH12", "lab_name": "4DN DCIC, HMS"}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}, "external_references": []}, {"upload_key": "b407b98e-d349-414d-b6f5-1e88450d6a70/4DNFIVQQ59LI.bw", "href": "/files-processed/4DNFIVQQ59LI/@@download/4DNFIVQQ59LI.bw", "accession": "4DNFIVQQ59LI", "file_size": 100344163, "@type": ["FileProcessed", "File", "Item"], "file_type_detailed": "read counts (bw)", "open_data_url": "https://4dn-open-data-public.s3.amazonaws.com/fourfront-webprod/wfoutput/b407b98e-d349-414d-b6f5-1e88450d6a70/4DNFIVQQ59LI.bw", "file_format": {"display_title": "bw", "@type": ["FileFormat", "Item"], "file_format": "bw", "@id": "/file-formats/bw/", "uuid": "d1311111-218e-4f61-aaf0-91f226248b2c", "status": "released", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "file_type": "read counts", "file_classification": "processed file", "status": "released", "display_title": "4DNFIVQQ59LI.bw", "@id": "/files-processed/4DNFIVQQ59LI/", "uuid": "b407b98e-d349-414d-b6f5-1e88450d6a70", "static_content": [{"description": "auto_generated_higlass_view_config", "location": "tab:higlass", "content": {"@type": ["HiglassViewConfig", "UserContent", "Item"], "@id": "/higlass-view-configs/f5f9c0be-25fc-4ed4-874a-d4f5062473ef/", "display_title": "4DNFIVQQ59LI - read counts for CH12 RNA-seq", "status": "released", "uuid": "f5f9c0be-25fc-4ed4-874a-d4f5062473ef", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin", "role.owner", "userid.7677f8a8-79d2-4cff-ab0a-a967a2a68e39"]}}}], "track_and_facet_info": {"experimental_lab": "Rafael Casellas, NIH", "experiment_type": "RNA-seq", "experiment_bucket": "processed file", "dataset": "RNA-seq on CH12", "condition": "WT", "replicate_info": "Biorep 2, Techrep 1", "biosource_name": "CH12", "lab_name": "4DN DCIC, HMS", "track_title": "read counts for CH12 RNA-seq"}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}, "external_references": []}, {"upload_key": "8b7718c2-eb90-4e55-b740-189c5fb06f88/4DNFICVOGV37.tsv", "href": "/files-processed/4DNFICVOGV37/@@download/4DNFICVOGV37.tsv", "accession": "4DNFICVOGV37", "file_size": 13213744, "@type": ["FileProcessed", "File", "Item"], "file_type_detailed": "gene expression (tsv)", "open_data_url": "https://4dn-open-data-public.s3.amazonaws.com/fourfront-webprod/wfoutput/8b7718c2-eb90-4e55-b740-189c5fb06f88/4DNFICVOGV37.tsv", "file_format": {"display_title": "tsv", "@type": ["FileFormat", "Item"], "file_format": "tsv", "@id": "/file-formats/tsv/", "uuid": "5e8f64b8-6323-410a-8af2-05aba0472f8e", "status": "released", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "file_type": "gene expression", "file_classification": "processed file", "status": "released", "display_title": "4DNFICVOGV37.tsv", "@id": "/files-processed/4DNFICVOGV37/", "uuid": "8b7718c2-eb90-4e55-b740-189c5fb06f88", "quality_metric": {"@id": "/quality-metrics-qclist/db9683c8-7aee-4bcf-b3ec-023f3e4a626b/", "status": "released", "overall_quality_status": "PASS", "@type": ["QualityMetricQclist", "QualityMetric", "Item"], "display_title": "QualityMetricQclist from 2020-05-13", "uuid": "db9683c8-7aee-4bcf-b3ec-023f3e4a626b", "quality_metric_summary": [{"title": "Reads mapped to protein-coding genes", "value": "27271618", "numberType": "integer"}, {"title": "Reads mapped to rRNA", "value": "23485", "numberType": "integer"}], "qc_list": [{"value": {"uuid": "4e8e2835-8df1-42c5-8b25-c0caf1b05b5f", "@type": ["QualityMetricRnaseq", "QualityMetric", "Item"], "display_title": "QualityMetricRnaseq from 2019-11-28", "@id": "/quality-metrics-rnaseq/4e8e2835-8df1-42c5-8b25-c0caf1b05b5f/", "status": "released", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}}, {"value": {"uuid": "f528d794-2fff-4105-891e-55f8c04313e4", "@type": ["QualityMetricRnaseqMadqc", "QualityMetric", "Item"], "display_title": "QualityMetricRnaseqMadqc from 2020-05-13", "@id": "/quality-metrics-rnaseq-madqc/f528d794-2fff-4105-891e-55f8c04313e4/", "status": "released", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}}], "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "track_and_facet_info": {"experimental_lab": "Rafael Casellas, NIH", "experiment_type": "RNA-seq", "experiment_bucket": "processed file", "dataset": "RNA-seq on CH12", "condition": "WT", "replicate_info": "Biorep 2, Techrep 1", "biosource_name": "CH12", "lab_name": "4DN DCIC, HMS"}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}, "external_references": []}, {"upload_key": "01f57247-e063-4306-84c6-25becbb6b883/4DNFIXM6NFVJ.tsv", "href": "/files-processed/4DNFIXM6NFVJ/@@download/4DNFIXM6NFVJ.tsv", "accession": "4DNFIXM6NFVJ", "file_size": 25851248, "@type": ["FileProcessed", "File", "Item"], "file_type_detailed": "isoform expression (tsv)", "open_data_url": "https://4dn-open-data-public.s3.amazonaws.com/fourfront-webprod/wfoutput/01f57247-e063-4306-84c6-25becbb6b883/4DNFIXM6NFVJ.tsv", "file_format": {"display_title": "tsv", "@type": ["FileFormat", "Item"], "file_format": "tsv", "@id": "/file-formats/tsv/", "uuid": "5e8f64b8-6323-410a-8af2-05aba0472f8e", "status": "released", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "file_type": "isoform expression", "file_classification": "processed file", "status": "released", "display_title": "4DNFIXM6NFVJ.tsv", "@id": "/files-processed/4DNFIXM6NFVJ/", "uuid": "01f57247-e063-4306-84c6-25becbb6b883", "track_and_facet_info": {"experimental_lab": "Rafael Casellas, NIH", "experiment_type": "RNA-seq", "experiment_bucket": "processed file", "dataset": "RNA-seq on CH12", "condition": "WT", "replicate_info": "Biorep 2, Techrep 1", "biosource_name": "CH12", "lab_name": "4DN DCIC, HMS"}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}, "external_references": []}], "project_release": "2019-12-03", "biosample_quantity": 1000000.0, "biosample_quantity_units": "cells", "@id": "/experiments-seq/4DNEXDWSGYS9/", "@type": ["ExperimentSeq", "Experiment", "Item"], "uuid": "faa9c6fa-43fa-4a81-9a08-1ab9c72dcc4f", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}, "display_title": "RNA-seq on CH12 - 4DNEXDWSGYS9", "external_references": [{"ref": "GEO:GSM2587427", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSM2587427"}], "experiment_sets": [{"@id": "/experiment-set-replicates/4DNES19UNBJ7/", "status": "released", "uuid": "c5ed7b60-3bf3-4224-8999-d0ab83328786", "accession": "4DNES19UNBJ7", "experimentset_type": "replicate", "@type": ["ExperimentSetReplicate", "ExperimentSet", "Item"], "display_title": "4DNES19UNBJ7", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}], "produced_in_pub": {"@type": ["Publication", "Item"], "uuid": "89ec268b-d05c-4841-8806-a49fb0d99e78", "title": "The Energetics and Physiological Impact of Cohesin Extrusion.", "journal": "Cell", "status": "current", "abstract": "Cohesin extrusion is thought to play a central role in establishing the architecture of mammalian genomes. However, extrusion has not been visualized in  vivo, and thus, its functional impact and energetics are unknown. Using ultra-deep Hi-C, we show that loop domains form by a process that requires cohesin ATPases. Once formed, however, loops and compartments are maintained for  hours without energy input. Strikingly, without ATP, we observe the emergence of  hundreds of CTCF-independent loops that link regulatory DNA. We also identify architectural \"stripes,\" where a loop anchor interacts with entire domains at high frequency. Stripes often tether super-enhancers to cognate promoters, and in B cells, they facilitate Igh transcription and recombination. Stripe anchors represent major hotspots for topoisomerase-mediated lesions, which promote chromosomal translocations and cancer. In plasmacytomas, stripes can deregulate Igh-translocated oncogenes. We propose that higher organisms have coopted cohesin extrusion to enhance transcription and recombination, with implications for tumor development.", "@id": "/publications/89ec268b-d05c-4841-8806-a49fb0d99e78/", "ID": "PMID:29706548", "date_published": "2018-04-26", "display_title": "Vian L et al. (2018) PMID:29706548", "authors": ["Vian L", "Pekowska A", "Rao SSP", "Kieffer-Kwon KR", "Jung S", "Baranello L", "Huang SC", "El Khattabi L", "Dose M", "Pruett N", "Sanborn AL", "Canela A", "Maman Y", "Oksanen A", "Resch W", "Li X", "Lee B", "Kovalchuk AL", "Tang Z", "Nelson S", "Di Pierro M", "Cheng RR", "Machol I", "St Hilaire BG", "Durand NC", "Shamim MS", "Stamenova EK", "Onuchic JN", "Ruan Y", "Nussenzweig A", "Levens D", "Aiden EL", "Casellas R"], "short_attribution": "Vian L et al. (2018)", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "publications_of_exp": [{"short_attribution": "Vian L et al. (2018)", "@type": ["Publication", "Item"], "ID": "PMID:29706548", "display_title": "Vian L et al. (2018) PMID:29706548", "abstract": "Cohesin extrusion is thought to play a central role in establishing the architecture of mammalian genomes. However, extrusion has not been visualized in  vivo, and thus, its functional impact and energetics are unknown. Using ultra-deep Hi-C, we show that loop domains form by a process that requires cohesin ATPases. Once formed, however, loops and compartments are maintained for  hours without energy input. Strikingly, without ATP, we observe the emergence of  hundreds of CTCF-independent loops that link regulatory DNA. We also identify architectural \"stripes,\" where a loop anchor interacts with entire domains at high frequency. Stripes often tether super-enhancers to cognate promoters, and in B cells, they facilitate Igh transcription and recombination. Stripe anchors represent major hotspots for topoisomerase-mediated lesions, which promote chromosomal translocations and cancer. In plasmacytomas, stripes can deregulate Igh-translocated oncogenes. We propose that higher organisms have coopted cohesin extrusion to enhance transcription and recombination, with implications for tumor development.", "journal": "Cell", "@id": "/publications/89ec268b-d05c-4841-8806-a49fb0d99e78/", "authors": ["Vian L", "Pekowska A", "Rao SSP", "Kieffer-Kwon KR", "Jung S", "Baranello L", "Huang SC", "El Khattabi L", "Dose M", "Pruett N", "Sanborn AL", "Canela A", "Maman Y", "Oksanen A", "Resch W", "Li X", "Lee B", "Kovalchuk AL", "Tang Z", "Nelson S", "Di Pierro M", "Cheng RR", "Machol I", "St Hilaire BG", "Durand NC", "Shamim MS", "Stamenova EK", "Onuchic JN", "Ruan Y", "Nussenzweig A", "Levens D", "Aiden EL", "Casellas R"], "uuid": "89ec268b-d05c-4841-8806-a49fb0d99e78", "date_published": "2018-04-26", "title": "The Energetics and Physiological Impact of Cohesin Extrusion.", "status": "current", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}], "experiment_categorizer": {"field": "Default", "value": null}, "experiment_summary": "RNA-seq on CH12", "@context": "/terms/", "aggregated-items": {"badges": [{"parent": "/biosamples/4DNBSMPEGHY3/", "embedded_path": "biosample.badges", "item": {"messages": ["Biosample missing Cell Culture Details"], "badge": {"commendation": null, "warning": "Biosample Metadata Incomplete", "uuid": "2b2cc7ff-b7a8-4138-9a6c-22884fc71690", "@id": "/badges/biosample-metadata-incomplete/", "badge_icon": "/static/img/badges/biosample-icon.svg", "description": "Biosample is missing metadata information required as part of the standards implemented by the 4DN Samples working group."}}}]}, "validation-errors": []}