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High-throughput  optical mapping of several hundred intra-chromosomal interactions in individual  human fibroblasts demonstrates low association frequencies, which are determined  by genomic distance, higher-order chromatin architecture, and chromatin  environment. The structure of TADs is variable between individual cells, and  inter-TAD associations are common. Furthermore, single-cell analysis reveals  independent behavior of individual alleles in single nuclei. Our observations  reveal extensive variability and heterogeneity in genome organization at the  level of individual alleles and demonstrate the coexistence of a broad spectrum  of genome configurations in a cell population.", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "publications_of_exp": [{"title": "Extensive Heterogeneity and Intrinsic Variation in Spatial Genome Organization.", "authors": ["Finn EH", "Pegoraro G", "Brandao HB", "Valton AL", "Oomen ME", "Dekker J", "Mirny L", "Misteli T"], "display_title": "Finn EH et al. (2019) PMID:30799036", "@id": "/publications/80007b23-7748-4492-9e49-c38400acbe60/", "status": "current", "@type": ["Publication", "Item"], "journal": "Cell", "date_published": "2019-03-07", "ID": "PMID:30799036", "short_attribution": "Finn EH et al. 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Our observations  reveal extensive variability and heterogeneity in genome organization at the  level of individual alleles and demonstrate the coexistence of a broad spectrum  of genome configurations in a cell population.", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}], "experiment_categorizer": {"field": "Enzyme", "value": "HindIII", "combined": "Enzyme: HindIII"}, "experiment_summary": "Dilution Hi-C on HFF-hTERT with HindIII", "@context": "/terms/", "aggregated-items": {"badges": [{"parent": "/biosamples/4DNBSGZGEU3X/", "embedded_path": "biosample.badges", "item": {"messages": ["Biosample missing doubling_number", "Biosample missing morphology_image"], "badge": {"commendation": null, "warning": "Biosample Metadata Incomplete", "uuid": "2b2cc7ff-b7a8-4138-9a6c-22884fc71690", "@id": "/badges/biosample-metadata-incomplete/", "badge_icon": "/static/img/badges/biosample-icon.svg", "description": "Biosample is missing metadata information required as part of the standards implemented by the 4DN Samples working group."}}}]}, "validation-errors": []}